hirudin-水蛭素
序号 专利号 名称
1 US2007016969 Expression vector for hirudin and transformed cells and transgenic animals containing said vector
2 US2006140929 Modified hirudin proteins and t-cell epitopes in hirudin
3 EP1636267 MODIFIED HIRUDIN PROTEINS AND T-CELL EPITOPES IN HIRUDIN
4 US2004228852 Use of increased molecular-weight hirudin as an anticoagulant in extracorporeal kidney replace therapy
5 US2005095685 "Anti-hirudin polyclonal antibodies and their use for the identification, immunopurification and quantitative determination of hirudin"
6 MXPA03007116 USE OF FUSION PROTEINS WHOSE N-TERMINAL PART IS A HIRUDIN DERIVATIVE FOR THE PRODUCTION OF RECOMBINANT PROTEINS VIA SECRETION BY YEASTS.
7 EP1364029 FUSION PROTEIN comprising hirudin and proinsulin or insulin
8 CY2259 Stable dry powders containing hirudin
9 US2002173620 Bifunctional fusion proteins formed from hirudin and TAP
10 WO0061121 USE OF MOLECULAR WEIGHT-AMPLIFIED HIRUDIN AS AN ANTICOAGULANT IN EXTRACORPOREAL RENAL REPLACEMENT THERAPY
11 EP1026505 A complex buffer system for the CZE analysis of hirudin
12 US6514730 Secretion of hirudin derivatives
13 US6028170 Analogs of hirudin
14 US5880258 Anticoagulant hirudin variants and methods for their production
15 US5972648 "Hirudin analogs, methods of manufacture thereof and anticoagulant compositions having these as active ingredients"
16 US5902735 "Functional DNA block and plasmid coding for hirudin, transformed yeast, method for hirudin, hirudin obtained, and its pharmaceutical use"
17 US5817309 Antidote for hirudin and synthetic thrombin inhibitors and method of use
18 US6719975 "Anti-hirudin polyclonal antibodies and their use for the identification, immunopurification and quantitative determination of hirudin"
19 WO9603425 PROCESS FOR FOLDING OF PROTEINS LIKE RECOMBINANT HIRUDIN OR EPIDERMAL GROWTH FACTOR
20 EP0804461 PROCESS FOR FOLDING OF PROTEINS LIKE RECOMBINANT HIRUDIN OR EPIDERMAL GROWTH FACTOR
21 US5824505 "Vectors, transformed cells and process for the preparation of hirudin"
22 US5837808 Analogs of hirudin
23 US5879926 "Yeast strains for the production of mature heterologous proteins, especially hirudin"
24 US5705355 "Hirudin, pharmaceutical compositions comprising it and their use"
25 US5650301 "Hirudin HV2 having ASN47LYS substitution, method of making, and method of use"
26 US5574012 Analogs of hirudin having anti-platelet activity
27 DE19513855 Use of polyethylene glycol-hirudin to treat unstable angina pectoris
28 US5821079 Vectors for the expression and secretion of hirudin by transformed yeasts
30 US6060451 Thrombin inhibitors based on the amino acid sequence of hirudin
31 US5591640 "Functional DNA block and plasmid coding for hirudin, transformed yeast, method for preparing hirudin, hirudin obtained and its pharmaceutical use"
32 US5767235 Anticoagulant hirudin variants and methods for their production
33 DE4445317 Topical compsns. contg. hirudin or heparin
34 US5573929 Secretion vector for hirudin or hirudin analog production
35 US5686564 Peptide derivatives corresponding to the carboxy terminal sequence of hirudin
36 US5547850 Process for determining hirudin and synthetic thrombin inhibitors
37 WO9507295 ANALOGS OF HIRUDIN
38 US5624822 Hirudin fusion proteins and preparation of hirudin
39 US5472938 Pharmaceutical depot compositions containing hirudin
40 US5541161 "Stabilized sulfonate, sulfate, phosphonate and phosphate derivatives of hirudin"
41 WO9315757 ANTIDOTE FOR HIRUDIN AND SYNTHETIC THROMBIN INHIBITORS
42 US5919895 Secretion of hirudin derivatives
43 WO9304082 ANALOGS OF HIRUDIN
44 US5272059 Monoclonal antibodies specific for hirudin
45 GB2257974 HIRUDIN ANALOGUES AND PROCESS FOR THEIR PREPARATION
46 US5304310 Method for concentrating and purifying hirudin from leeches
47 IE922081 "ANTI-HIRUDIN POLYCLONAL ANTIBODIES AND THEIR USE FOR THEIDENTIFICATION, IMMUNOPURIFICATION AND QUANTITATIVEDETERMINATION OF HIRUDIN"
48 US5538946 Hirudin derivatives with delayed action
49 US5663141 Hirudin/polyalkylene glycol conjugates and hirudin muteins
50 PT100299 "Hirudin analogue, method for the production thereof and anticoagulant containing it, and secretion vector, microorganisms transformed with said vector, and method for the production of products from said microorganisms"
51 WO9215610 "HIRUDIN ANALOGUE OR SALT THEREOF, PRODUCTION THEREOF, AND ANTICOAGULANT CONTAINING THE SAME AS ACTIVE INGREDIENT"
52 US5296352 Monoclonal antibodies directed against complexes formed by thrombin and hirudin
53 US5204323 Heparin and hirudin antidotal compositions and methods
54 WO9205748 SOLUBLE HIRUDIN CONJUGATES
55 WO9201712 ANALOGS OF HIRUDIN
56 IE912566 ORAL PHARMACEUTICAL COMPOSITIONS CONTAINING HIRUDIN
57 EP0443429 "Stabilized sulfonate, sulfate, phosphonate and phosphate derivatives of hirudin."
58 WO9109946 METHOD OF PREPARATION OF HIRUDIN
59 US5112615 Soluble hirudin conjugates
60 US5095092 PROCESS FOR THE ISOLATION AND PURIFICATION OF HIRUDIN
61 GB2247239 Hirudin conjugates with polyoxyethylene
62 IE902877 "EXPRESSION VECTOR FOR HIRUDIN, HIRUDIN FUSION PROTEIN,TRANSFORMED MICROORGANISM AND METHOD FOR PRODUCTION OFHIRUDIN"
63 WO9101328 HIRUDIN PEPTIDE DERIVATIVES
64 DE4014260 "New hirudin-poly:alkylene glycol conjugate(s) - used as anticoagulants for treatment and prophylaxis of myocardial infarct, arterial occlusion, venous thrombosis and pulmonary embolism"
65 DE4011375 "New anticoagulant hirudin-polyvinyl lactam conjugates - for treating e.g. myocardial infarction, peripheral arterial occlusion disorders, deep venous thrombosis and pulmonary embolism"
66 GB2242681 Hirudin fragments
67 EP0396436 "Improved yeast strains for the production of mature heterologous proteins, in particular of hirudin."
68 EP0357242 Hirudin-coated biocompatible substance.
69 US5164304 METHOD AND VECTORS FOR STABILIZING HIRUDIN AND HUMAN LAMININ B1 EXPRESSION
70 WO9003391 HIRUDIN PEPTIDES
71 US5087613 HIRUDIN VARIANTS
72 EP0333356 Hirudin peptides.
73 EP0372670 Hirudin peptides for inhibiting platelet aggregation.
74 DE3900626 Hirudin derivative
75 EP0352387 Method for preparing a hirudin.
76 IE871762L FUNCTIONAL DNA BLOCK AND PLASMID CODING FOR HIRUDIN;TRANSFORMED YEAST
77 FR2611723 "Recombinant DNA expression vector which encodes hirudin, cultures of infected or transformant mammalian cells, process for preparing hirudin and protein obtained"
78 FR2607516 "Improved vectors for expressing a variant of hirudin in yeasts, process and product obtained."
79 US4767742 "Hirudin-PA and its derivatives, process for manufacturing these and the use of these substances"
80 FR2601383 "Improved vectors for the expression of hirudin in yeasts, process and product obtained"
81 IE58485 "A genetic engineering process for the preparation of hirudins, and means for carrying out this process"
82 EP0158564 "Expression vectors for hirudin, transformed cells and process for the preparation of hirudin."
83 FR2569420 "Vector for expressing hirudin, process for preparing it by culturing transformed cells and the hirudin obtained"
84 FR2562088 "Vectors for expressing hirudin, transformed cells and process for preparing hirudin."
85 GB1032323 Process for the production of purified hirudin
86 GB1031840 Process for the production of hirudin
美国专利目录:
PAT. NO. Title
1 6,719,975 Anti-hirudin polyclonal antibodies and their use for the identification, immunopurification and quantitative determination of hirudin
2 6,514,730 Secretion of hirudin derivatives
3 6,060,451 Thrombin inhibitors based on the amino acid sequence of hirudin
4 6,028,170 Analogs of hirudin
5 5,972,648 Hirudin analogs, methods of manufacture thereof and anticoagulant compositions having these as active ingredients
6 5,919,895 Secretion of hirudin derivatives
7 5,919,762 Conjugates of hirudin and lipophilic compounds
8 5,902,735 Functional DNA block and plasmid coding for hirudin, transformed yeast, method for hirudin, hirudin obtained, and its pharmaceutical use
9 5,880,258 Anticoagulant hirudin variants and methods for their production
10 5,879,926 Yeast strains for the production of mature heterologous proteins, especially hirudin
11 5,866,399 Process for inactivating carboxypeptidase Y in hirudin-containing culture broths
12 5,837,808 Analogs of hirudin
13 5,824,505 Vectors, transformed cells and process for the preparation of hirudin
14 5,821,079 Vectors for the expression and secretion of hirudin by transformed yeasts
15 5,817,309 Antidote for hirudin and synthetic thrombin inhibitors and method of use
16 5,767,235 Anticoagulant hirudin variants and methods for their production
17 5,705,355 Hirudin, pharmaceutical compositions comprising it and their use
18 5,698,104 Purification process for hirudin using affinity chromatography
19 5,686,564 Peptide derivatives corresponding to the carboxy terminal sequence of hirudin
20 5,674,838 Hirudin derivatives and a process for their preparation
21 5,663,141 Hirudin/polyalkylene glycol conjugates and hirudin muteins
22 5,650,301 Hirudin HV2 having a SN7LYS substitution, method of making, and method of use
23 5,624,822 Hirudin fusion proteins and preparation of hirudin
24 5,591,640 Functional DNA block and plasmid coding for hirudin, transformed yeast, method for preparing hirudin, hirudin obtained and its pharmaceutical use
25 5,574,012 Analogs of hirudin having anti-platelet activity
26 5,573,929 Secretion vector for hirudin or hirudin analog production
27 5,547,850 Process for determining hirudin and synthetic thrombin inhibitors
28 5,541,161 Stabilized sulfonate, sulfate, phosphonate and phosphate derivatives of hirudin
29 5,538,946 Hirudin derivatives with delayed action
30 5,516,656 Production of a new hirudin analog and anticoagulant pharmaceutical composition containing the same
31 5,472,938 Pharmaceutical depot compositions containing hirudin
32 5,362,858 Polyethylene glycol-hirudin conjugates, process for preparing them and their use for the treatment of thromboses
33 5,304,310 Method for concentrating and purifying hirudin from leeches
34 5,296,352 Monoclonal antibodies directed against complexes formed by thrombin and hirudin
35 5,272,059 Monoclonal antibodies specific for hirudin
36 5,204,323 Heparin and hirudin antidotal compositions and methods
37 5,180,668 Hirudin derivative
38 5,167,960 Hirudin-coated biocompatible substance
39 5,164,304 Method and vectors for stabilizing hirudin and human laminin B.sub.1 expression
40 5,118,790 Analogs of hirudin
41 5,112,615 Soluble hirudin conjugates
42 5,095,092 Process for the isolation and purification of hirudin
43 5,087,613 Hirudin variants
44 4,767,742 Hirudin-PA and its derivatives, process for manufacturing these and the use of these substances
PUB. APP. NO. Title
1 20050095685 Anti-hirudin polyclonal antibodies and their use for the identification, immunopurification and quantitative determination of hirudin
2 20040228852 Use of increased molecular-weight hirudin as an anticoagulant in extracorporeal kidney replace therapy
3 20030176673 Nucleic acids, proteins, and processes thereof such as use of fusion proteins whose N-terminal part is a hirudin derivative for the production of recombinant proteins via secretion by yeasts
4 20020173620 Bifunctional fusion proteins formed from hirudin and TAP
